Clinical Scientist (Registered and Pre-Registered)
Oncologica provides precision oncology testing to address the growing demand for molecular profiling of cancer patients for targeted therapies. Oncologica delivers state-of-the-art molecular tissue analytics for cancer diagnosis, patient stratification and personalised medicine to maximise treatment benefit and reduce healthcare costs. We perform new generation molecular profiling for cancer targeted therapies utilising high-throughput next generation sequencing platforms (NGS) and molecular probes (FISH/CISH/DDISH) for detection of actionable mutations, fusion transcripts and copy number variations. Our portfolio of services also include IHC protein expression profiling for protein based companion diagnostics.
Oncologica also functions as a Contract Research Organisation to support biomarker and drug development programmes worldwide. We capitalise on our extensive knowledge base in anatomical and molecular oncopathology to provide high quality and cost effective Contract Research Services to support theranostic programmes at all stages of the development pipeline, from discovery through preclinical development to clinical trials.
In addition, Oncologica runs its own in-house R&D programmes focusing on the development of novel diagnostic and therapeutic intervention strategies targeting the cell cycle machinery.
The principal role for this appointment is to assist with the day-to-day delivery of the Diagnostic Genomic Services for Oncologica Ltd. This role will include, but is not limited to, quality control of NGS data, interpreting complex NGS data to determine pathogenicity and to produce the clinical report to guide patient care. The post holder will also assist with the validation and verification of new tests, contributing to scientific publications and maintaining contribute to the Oncologica Quality Management System.
The hours of work are 37.5; the distribution of these hours is at the discretion of the Scientific Director.
Oncologica has adopted an equal opportunities policy and specific regard should be taken of its content in relation to the treatment of employees or potential employees.
Overseas applicants must hold professional qualifications equivalent to membership of the Association of Clinical Scientists and registration of the Healthcare Professions Council state registration in the UK. It is expected that proof of acceptance by these UK bodies for membership to perform diagnostics services within the UK would be required by all overseas applicants.
This job description is not meant to be restrictive or exhaustive and duties may change in response to changing circumstances. These will be discussed with the post holder.
What You Do
Assist in the efficient day-to-day running and delivery of the Clinical service including:
Assist the Lead Clinical Scientist in the interpretation of clinical NGS data and the construction of clinical reports.
Monitor the quality of data produced by next generation sequencing and other technologies, to ensure it meets the standards required for the diagnostic service.
To help maintain and improve the analysis pipeline for Next Generation Sequencing data for the Molecular Diagnostic Profiling Service.
To aid in maintaining the databases for storage of scientific and clinical information, diagnostic test results, etc, and to establish links for submission to external databases where appropriate.
Responsible for ensuring the Laboratory complies with all requirements of Data Protection, liaising with the IT Governance as required.
Maintain an awareness of the relevant scientific literature.
To write and contribute to the writing of publications.
To attend seminars and other departmental meetings as required.
To participate in any laboratory duties as required.
To contribute to the business development of the Molecular Diagnostics Profiling Service of Oncologica.
To participate in UK NEQAS Molecular Genetics and UK NEQAS ICC&ISH as required
To be aware of and act upon:
– Disciplinary procedures
– Disciplinary rules
– Grievance procedures
– Section 7 & 8 of the Health & Safety at Work Act
– Organisational Fire Guidelines
– Equal Opportunities Policy
- HCPC registered Clinical Scientist
- Knowledge of molecular biology and genomics
- An understanding of the principals of DNA sequence analysis, especially Next-generation sequencing.
- Experience in the identification of genetic variants associated with disease and the downstream analysis of this data.
- Familiar with commonly used databases and bioinformatics tools for NGS data analysis (eg., IGV, SIFT, UCSC Genome Browser, etc.)
- Experience of data management and processing, with a demonstration of sensitivity to issues of confidentiality and knowledge of the Data Protection Act and Freedom of Information Act.
- Excellent communication skills, verbal and written, including presentation and report writing skills.
- Experience of UKAS/ISO/GCLP standards and of a Quality Management System
- Ability to write protocols and other QMS documents
- Knowledge and awareness of Health & Safety issues
- Show evidence of commitment to continuing personal and professional development
- Proficient with various IT systems
- Ability to work to deadlines
- Maintain confidentiality and act in a professional manner
- Experience of public speaking at national or international meetings.
- Experience of liaising with clinicians and health care professionals.